Apotex Inc. has formulated their pharmaceuticals to contain the exact same
chemical and to produce the same beneficial effects as the original brand name products
they replace. The testing methods employed in Canada are some of the most rigorous used
anywhere in the world and they incorporate bioequivalence studies comparing the two
products. Proof that the Apotex product is equivalent to the originator's product is
provided by the Therapeutics Products Program of Health Canada, the Canadian Regulatory
Agency, in their declaration of equivalence.
A typical example of the result of a bioequivalence study is illustrated
in the following graph, which shows the concentration of the drug in the serum at each
point in time, comparing the originator's brand in red with the Apotex brand in blue. Once
the active drug is circulating in the body, all brands will perform the same at the same
concentration.